pI: 6.7681 |
Length (AA): 400 |
MW (Da): 44339 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 399 | 2cy8 (A) | 4 | 446 | 13.00 | 0 | 1 | 0.92 | 0.59 |
3 | 386 | 2bwn (A) | 2 | 394 | 49.00 | 0 | 1 | 1.6 | -0.88 |
3 | 389 | 2bwn (A) | 2 | 397 | 48.00 | 0 | 1 | 1.52 | -0.92 |
3 | 386 | 2bwn (A) | 2 | 394 | 49.00 | 0 | 1 | 1.61 | -0.9 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126783)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G04620 | 7-keto-8-aminopelargonic acid (KAPA) synthase |
Brugia malayi | Bm1_01535 | 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial precursor |
Candida albicans | CaO19.2601 | similar to S. cerevisiae HEM1 (YDR232W) mitochondrial 5-aminolevulinic acid synthase involved in heme biosynthesis |
Candida albicans | CaO19.10132 | similar to S. cerevisiae HEM1 (YDR232W) mitochondrial 5-aminolevulinic acid synthase involved in heme biosynthesis |
Caenorhabditis elegans | CELE_T25B9.1 | Protein T25B9.1 |
Dictyostelium discoideum | DDB_G0280763 | 5-aminolevulinate synthase |
Drosophila melanogaster | Dmel_CG3017 | Aminolevulinate synthase |
Drosophila melanogaster | Dmel_CG10361 | CG10361 gene product from transcript CG10361-RA |
Escherichia coli | b0776 | 8-amino-7-oxononanoate synthase |
Escherichia coli | b3617 | glycine C-acetyltransferase |
Echinococcus granulosus | EgrG_000107200 | 2 amino 3 ketobutyrate coenzyme A ligase |
Echinococcus granulosus | EgrG_000574600 | 5 aminolevulinate synthase |
Echinococcus granulosus | EgrG_000575200 | 5 aminolevulinate synthase |
Echinococcus multilocularis | EmuJ_000107200 | 2 amino 3 ketobutyrate coenzyme A ligase |
Echinococcus multilocularis | EmuJ_000574600 | 5 aminolevulinate synthase |
Echinococcus multilocularis | EmuJ_000575200 | 5 aminolevulinate synthase |
Homo sapiens | ENSG00000158578 | 5'-aminolevulinate synthase 2 |
Homo sapiens | ENSG00000023330 | 5'-aminolevulinate synthase 1 |
Homo sapiens | ENSG00000100116 | glycine C-acetyltransferase |
Loa Loa (eye worm) | LOAG_04085 | 2-amino-3-ketobutyrate coenzyme A ligase |
Mycobacterium leprae | ML1217 | PROBABLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF (AONS) (8-AMINO-7-KETOPELARGONATE SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTHE |
Mus musculus | ENSMUSG00000006378 | glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase) |
Mus musculus | ENSMUSG00000025270 | aminolevulinic acid synthase 2, erythroid |
Mus musculus | ENSMUSG00000032786 | aminolevulinic acid synthase 1 |
Mycobacterium tuberculosis | Rv1569 | Probable 8-amino-7-oxononanoate synthase BioF1 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synth |
Mycobacterium tuberculosis | Rv0032 | Possible 8-amino-7-oxononanoate synthase BioF2 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synth |
Mycobacterium ulcerans | MUL_4045 | 8-amino-7-oxononanoate synthase |
Mycobacterium ulcerans | MUL_1560 | 8-amino-7-oxononanoate synthase |
Mycobacterium ulcerans | MUL_0241 | 8-amino-7-oxononanoate synthase |
Mycobacterium ulcerans | MUL_1966 | 8-amino-7-oxononanoate synthase |
Mycobacterium ulcerans | MUL_2843 | 8-amino-7-oxononanoate synthase |
Neospora caninum | NCLIV_027820 | 5-aminolevulinic acid synthase, related |
Oryza sativa | 4349380 | Os10g0560900 |
Oryza sativa | 4327870 | Os01g0736400 |
Plasmodium berghei | PBANKA_1459200 | delta-aminolevulinic acid synthetase |
Plasmodium falciparum | PF3D7_1246100 | delta-aminolevulinic acid synthetase |
Plasmodium knowlesi | PKNH_1465700 | delta-aminolevulinic acid synthetase, putative |
Plasmodium vivax | PVX_101195 | delta-aminolevulinic acid synthetase, putative |
Plasmodium yoelii | PY05459 | delta-aminolevulinic acid synthetase |
Saccharomyces cerevisiae | YDR232W | 5-aminolevulinate synthase |
Schistosoma japonicum | Sjp_0209020 | ko:K00643 5-aminolevulinate synthase [EC2.3.1.37], putative |
Schistosoma mansoni | Smp_045260 | 5-aminolevulinic acid synthase |
Schmidtea mediterranea | mk4.000755.02 | 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial |
Schmidtea mediterranea | mk4.052690.00 | 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial |
Schmidtea mediterranea | mk4.042742.00 | 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial |
Schmidtea mediterranea | mk4.042742.01 | 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial |
Schmidtea mediterranea | mk4.000655.01 | 5-aminolevulinate synthase, nonspecific, mitochondrial |
Trypanosoma brucei gambiense | Tbg972.8.6090 | 2-amino-3-ketobutyrate coenzyme A ligase, putative,glycine acetyltransferase, putative |
Trypanosoma brucei | Tb927.8.6060 | glycine acetyltransferase, putative |
Trypanosoma congolense | TcIL3000_8_5850 | glycine acetyltransferase, putative |
Trypanosoma cruzi | TcCLB.511899.40 | 2-amino-3-ketobutyrate coenzyme A ligase, putative |
Trypanosoma cruzi | TcCLB.511899.10 | 2-amino-3-ketobutyrate coenzyme A ligase, putative |
Trypanosoma cruzi | TcCLB.511071.140 | 2-amino-3-ketobutyrate coenzyme A ligase, putative |
Toxoplasma gondii | TGME49_258690 | 5-aminolevulinic acid synthase domain-containing protein |
Wolbachia endosymbiont of Brugia malayi | Wbm0133 | 5-aminolevulinate synthase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu1597 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu32 | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb927.8.6060 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.6060 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.6060 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.6060 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0776 | Escherichia coli | non-essential | goodall |
b3617 | Escherichia coli | non-essential | goodall |
YDR232W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1459200 | Plasmodium berghei | Dispensable | plasmo |
TGME49_258690 | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Plasmodium falciparum | delta-aminolevulinic acid synthetase | Compounds | References |